![]() ![]() then R 2 is not -C(═O)(O-(C 1-C 25)alkyl) and.Z′ represents H, (C 1-C 10)alkyl, or (C 1-C 10)alkoxy, and wherein Z′ is optionally substituted with (C 1-C 6)alkyl, oxo, or (C 1-C 6)alkoxy.each of R x and R z are independently optionally substituted with (C 1-C 6)alkyl, oxo, or (C 1-C 6)alkoxy and.R x and R z are independently chosen from H, (C 1-C 6)alkyl, and (C 6-C 10)cycloalkyl,.wherein Z represents a bond, (C 1-C 10)alkyl, C(R x)(R z),.when R 3a is H, R 3b is H, and R 5 is H, then R 2 is not H, -C(═O)((C 1-C 5)alkyl), or -C(═O)(Z-butyl-Z′),.wherein the steroid derivative is optionally substituted with one to four groups independently selected from -OH and (C 1-C 12)alkyl.each R h independently represents a steroid derivative or a bridged, spirocyclic, or fused polycyclic (C 7-C 18)carbocycle,.each L independently represents (C 1-C 18)alkylenyl.each R f independently represents (C 1-C 18)alkyl.each R c1 and R c2 represents -NH-L-C(═O)(O-R f) and -NH-L-C(═O)(O-R g), which can be the same or different. ![]() wherein each R b is optionally substituted with from one to three groups independently chosen from R f, -CH 2-O-C(═O)(R f), and -O-C(═O)(R f).each R b represents phenyl or cyclohexyl,.wherein each R a is optionally substituted with one R b.each R a represents (C 1-C 25)alkyl, which can be the same or different.a dashed line (), in conjunction with the solid line to which it is parallel, represents an optional double bond.SUMMARYĭisclosed herein are, for instance, compounds of formula (I): Improved treatments for HIV and other viral infections are desirable. No cure is known, and accordingly those affected by HIV can require life-long treatments, which can include taking one or more treatments per day and can have various side effects. Human immunodeficiency virus (HIV) infection is a life-threatening and serious disease of major public health significance affecting tens of millions of people worldwide. The present disclosure relates to compounds, compositions, and methods for treating viral infections. 2020, titled “PRODRUGS OF 4′-C-SUBSTITUTED-2-HALO-2′DEOXYADENOSINE NUCLEOSIDES AND METHODS OF MAKING AND USING THE SAME,” the entirety of which is incorporated herein by reference. This application claims the benefit of priority to U.S.
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